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Earlier risk estimate: ~1 in 10,000 patients New finding: ~1 in 2,500 patients No known treatment for NAION Other reported conditions include optic nerve inflammation, maculopathy, and worsening diabetic retinopathy

Steady dose escalation to higher doses than for glycaemic control are indicated if: BMI is 30 kg/m 2 , or BMI 27 to 30 kg/m 2 , and for the range 2730 kg/m 2 if there is one weight-related comorbidity (hypertension, dyslipidaemia, cardiovascular disease, obstructive sleep apnoea, prediabetes or T2D

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doi:10.1016/j.bbrc.2017.06.031 41

in short, cells were stimulated in the manufacturers stimulation buffer for the indicated time period at 37 C, before addition of the chemiluminescent substrate and luminescence read after a further 60 min incubation at room temperature