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16637, Aug
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Expert Review of Clinical Pharmacology

Thyroid cancer The prescribing information for GLP-1RA lists MTC as a contraindication, based on a preclinical rodent study demonstrating that GLP-1R activation elevates cAMP levels in rodent thyroid C-cells, stimulates calcitonin release, and promotes C-cell hyperplasia and MTC development (200)

To further evaluate the reliability of the evidence, we assessed the degree of overlap among systematic reviews using the CCA method (Supplementary data 4)
