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Patients taking these medications typically require dose reductions of their insulin or sulfonylurea before starting Zepbound, with careful glucose monitoring during titration

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In South Africa, these medicines remain largely inaccessible given their high costs, despite the large public health need for effective treatments for diabetes and obesity

This 6.5 percentage point difference is clinically meaningful and represents one of the primary reasons people choose tirzepatide over semaglutide

Lipid Metabolism In the SURPASS and SURMOUNT phase 3 clinical trial programs (Tables 1 and 2), treatment with tirzepatide was related to an improvement in the lipid profile, with major decreases in triglycerides (Table 4) that cannot be fully accounted for by reductions in weight alone [77]