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The problem with obesity is that it is chronic and it is multifactorial, Dr Yates said

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Neurobiologically, it involves hyperactivity in cortico-limbic circuits, such as the amygdala, insula, and orbitofrontal cortex, which can override satiety signals and drive compulsive intake [123, 124]

Lifestyle Factors That Support GLP-1 Production Your broader lifestyle may also shape how well your body produces and responds to GLP-1, including: Exercise: Both human and animal research shows aerobic activity may increase GLP-1 secretion, and consistent movement also supports gut microbiome health, which may further support L-cell hormone release

A spokesperson from Eli Lilly also said that hair loss has been observed with weight loss interventions and that the side effect is listed on Zepbound labels but not Mounjaro, as it is an adjunct to diet and exercise to help improve glycemic control in adults with type 2 diabetes