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An ion channel Ano1 mediates Ca 2+ -activated Cl pathways in ICCs, and a novel variant Ano1 1,2,3 (5) (whose expression generates a decreased density of Ca 2+ -activated Cl channels with slower kinetics compared to standard Ano1) was found at several-fold higher levels in the gastric muscle of patients with diabetic and idiopathic gastroparesis compared with normal controls [43]

The risk of worsening heart failure events alone dropped by 46% (HR 0.54)

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