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One thing these drugs do is reduce the size of fat cells
Clin Obes 13(5):e12593 Gloy VL et al (2013) Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials

If sedation intensifies, your doctor may reduce hydroxyzine temporarily or switch to a non-sedating antihistamine like cetirizine or fexofenadine, which don't interact with semaglutide