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For feet, this means: Loss of the intrinsic foot muscles that support the arch Reduced calf muscle mass affecting ankle proprioception and Achilles tendon loading Increased fall risk from reduced lower extremity strength The solution: Resistance training during GLP-1 treatment is critical not optional

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Novo Nordisk has launched two large Phase III trials (EVOKE and EVOKE+) to assess whether semaglutide can slow cognitive decline in participants with early-stage Alzheimers disease

This is an incidental pharmacological effect rather than its intended mechanism of action