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Around 20-25% of the weight lost on retatrutide is muscle and bone rather than fat, similar to other drugs in this family

doi:10.1016/j.ejphar.2024.177095 Li W, Zhou Q, Cong Z, et al

The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

Statistical software R (version 3.5.1) was used for the analysis.12 The sensitivity analysis consists of replicating the results of the meta-analysis, excluding at each step, each of the studies included in the review

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