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Although prospective studies specifically targeting PCOS + MASLD with pregnancy outcomes as the primary endpoint are currently lacking, a robust inference can be drawn based on the pathophysiological framework of MASLD and evidence from the general population: proactively identifying and reducing MASLD and ectopic fat load prior to pregnancy may be a key step in improving both periconception outcomes and long-term prognosis (68, 76)

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Approved by the FDA for type 2 diabetes management (as Ozempic and Rybelsus) and chronic weight management (as Wegovy), semaglutide represents a significant advancement in GLP-1-based therapeutics

For many, these digestive improvements contribute as much to quality of life as the weight management benefits