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Appl Environ Microbiol 76(9):30483051

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This prolonged retention increases pressure, fullness, and discomfort, especially after larger, protein-dense, or high-fat meals, even though digestion continues normally and food is not physically blocked. Large meal volume and gastric distension Larger meal volumes cause the stomach to stretch

ZEUS will enrol 6200 participants with stage 3 or 4 CKD and elevated hsCRP levels, with a primary MACE outcome and secondary kidney endpoints including kidney disease progression, UACR reductions and eGFR slope