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Given the powerful role of this hormone, its no surprise that researchers developed medications to target it for diabetes management and later, for weight loss

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10.3748/wjg.v18.i3.212 30 ElsaidM

The results of the TRANSCEND-T2D-1 trial, published in March 2026, showed that participants with type 2 diabetes mellitus, who took retatrutide 12mg, lost an average of 16.8% of their body weight at 40 weeks