glp-1 degradation Figure 4 from Glucagon-like peptide-1: glucose homeostasis and beyond Conjugation with glucagon like peptide-1

Importantly, this effect often attenuates over time with long-acting agents (tachyphylaxis), though the weight loss and glycemic benefits typically persist

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It has been hypothesized that the effects of GLP-1R agonists to reduce energy intake are at least partially driven by nausea and other GI AEs

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