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(2021) Differential effects of bile acids on the postprandial secretion of gut hormones: a randomized crossover study

[95] analyzed a systematic review that included 9 GLP-1RAs trials and 13 SGLT2i trials, confirming that the reduction in HbA1c by GLP-1RAs may increase the risk of MACE

The trial also reported dose-dependent increases in heart rate that peaked at 24 weeks and declined thereafter

45,160 In summary, most of the studied drugs did not show clinically significant DDIs related to delayed gastric emptying caused by GLP-1 RAs or a dual GLP-1/GIP RA administration

Natriuresis and Diuresis Studies in people living with T2DM and obesity have shown that GLP-1 RA administration can induce diuresis and natriuresis [110, 111] that likely contribute to the renoprotective effects of GLP-1 RA