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Current UK prescribing information (SmPCs) for licensed GLP-1 receptor agonists does not list a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2) as a contraindication, though individuals with such a history should discuss this with their clinician as a precautionary measure

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Research suggests GIP receptor activation helps redirect energy storage away from visceral (dangerous belly) fat toward subcutaneous fat, which carries fewer health risks

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Since insulin could not yet be measured, these studies required complex cross-circulation experiments [3], and incretin research hardly advanced

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