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Comparing tirzepatide with placebo, the two studies found an estimated treatment difference of 20.0 events per hour and 23.8 events per hour, respectively

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The study used a cross-over design, meaning that the 30 human volunteers would first receive the same 60 milligram dose of either Nexafed or Sudafed, have blood drawn at various times for pseudoephedrine measurements, and then be subject to a "washout" period during which the drug is completely metabolized and eliminated

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Participants who titrated from the lowest starting dose (2mg) generally achieved slightly better outcomes at the 12mg target