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Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial Summary: In individuals with both overweight/obesity and type 2 diabetes, the STEP 2 trial reported a mean weight loss of -9.6% with semaglutide 2.4 mg and a mean HbA1c reduction of 1.6%

The Role of Energy Compensation Continuing the analogy, your body becomes more efficient at using the fuel you provide as you lose weight, especially with regular exercise

One National Institutes of Health study tracked over 80,000 electronic health records of patients with obesity and no prior diagnosis of AUD

In the REDEFINE 1 phase 3 trial (NCT05567796), which enrolled adults with overweight or obesity (BMI 27 kg/m) and at least 1 weight-related comorbidity but without type 2 diabetes, participants receiving CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) achieved a mean body weight reduction of 22.7% from baseline after 68 weeks among adherent participants, compared with approximately 3% in the placebo group.5 These results establish CagriSema as one of the most potent antiobesity therapies investigated to date