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Common side effects included diarrhoea and nausea and there were some serious gastrointestinal side effects (9.8% in the control group and 6.4% in placebo). Semaglutide has also more recently been linked to the stomach-paralyzing condition gastroparesis, which has resulted in 1090 personal injury lawsuits in the US
129 These risks were greater with higher doses and longer durations of use

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The role of MOTS-c in humans will need larger controlled trials
