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In antidepressant prescribing, that approach can backfire by worsening early side effects and increasing early discontinuation

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Lipitor (atorvastatin) PfizerArchetype: Commodity Oral The worlds best-selling drug through most of the 2000s, Lipitor generated over $125 billion for Pfizer during its patent life

Dehydration resulting from reduced fluid intake (due to decreased appetite) or from gastrointestinal side effects such as nausea, vomiting, or diarrhea may precipitate headaches