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And if there was a significant time gap between stopping the medication and developing symptoms, establishing causation becomes more challenging
The action on kidneys appears to be directly through the effects also on renin-secreting cells of the juxta-glomerular apparatus, whose stimulation may lead to increased natriuresis and reduce hyperfiltration, and indirectly by the reduction of angiotensin II levels, the increase in nitric oxide with consequently endothelial vasodilation and the improvement of risk factors of kidney disease (hyperglycemia, hypertension, obesity) ( Figure 2 )
It regulates insulin, slows gastric emptying, and increases satiety

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Semaglutide (Ozempic): An initial dose of 0.25 mg is administered subcutaneously on a weekly basis for the first month, which is then increased to 0.5 mg weekly
