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The independent effects included in the model were treatment, region, strata (renal function for PIONEER 5 and insulin regimen for PIONEER 8), background medication and interaction between treatment and background medication as categorical fixed effects and baseline value as a covariate, all nested within visit, and using an unstructured residual covariance matrix

Tirzepatide is a dual GLP-1/GIP receptor agonist that has shown even greater weight loss in clinical trialsaveraging 22.5% of body weight over 72 weeks

doi: 10.1111/nbu.12559

The Mounjaro manufacturer recommends using barrier contraception, such as condoms, for four weeks after starting the drug or a dosage increase, or to switch to a non-oral contraception, such as an IUD or Nexplanon implant

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