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The long-acting nature of the medication makes the precise timing of a makeup dose less critical within this window, but still maintains the weekly rhythm

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Age, baseline metabolic health, and concurrent medications can also affect tolerance

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In the Phase 3 ATTAIN-1 trial published in the New England Journal of Medicine in 2025, once-daily orforglipron produced mean body weight reductions of 7.5% (6 mg), 8.4% (12 mg), and 11.2% (36 mg) at 72 weeks, compared with 2.1% for placebo