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It is a predictable consequence of treating the symptom (appetite) without addressing the cause (the internal environment driving weight gain)

Dig Dis Sci (1993) 38:66573.10.1007/BF01316798 6 GutzwillerJPGokeBDreweJHildebrandPKettererSHandschinDet alGlucagon-like peptide-1: a potent regulator of food intake in humans

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Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy

Of particular interest, the discovery of GLP-1 receptor expression in the myocardium and in the vascular endothelium suggested possible roles of GLP-1 in the cardiovascular system and multiple preclinical studies support cardioprotective effects of native GLP-1 (Fig