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Additionally, P9 induces interleukin-6 (IL-6) secretion from the intestine, which subsequently stimulates GLP-1 secretion by intestinal L-cells and pancreatic -cells, and also affects Icam2 mRNA expression, which suggests the normal expression of Icam-2 and the effects of P9 in glucose homeostasis may require IL-6 [160] (Fig

Can years of GLP-1 receptor stimulation eventually cause the same C-cell problems seen in two-year rodent studies

But the drugs will still be too pricey for many, they say

When the study group was stratified by BMI, adults without obesity, those with class I obesity (BMI: 30-34.99 kg/m2) and those with class II obesity (BMI: 35-39.99 kg/m2) were less likely to have all-cause hospital admissions, ED visits, undergo an endoscopic procedure, receive a prescription for a prokinetic, and receive a laxative prescription if they used an incretin-based drug compared with nonusers

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