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Background Globally, obesity has emerged as a significant public health concern, imposing detrimental impacts on human health

The day you take a GLP-1 injection matters less than consistency, meal timing, and individual biomarker response

However, PKA inhibition but not GLP-1R blockade eliminated the protective effects of metformin on endothelial function

While Berberine is touted as a natural alternative to Ozempic, its AMPK modulation differs from GLP-1 pathways, highlighting the need for cautious use.

To overcome this limitation, various modifications and delivery strategies to enhance the pharmacokinetic properties and therapeutic efficacy of GLP-1 analogs have been studied
