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Description
Pregnancy with T2DM is a high-risk condition for major congenital anomalies, among other adverse outcomes, thus emphasizing the need for glycemic control during this period

GLP-1 microdosing uses sub-therapeutic doses (0.05-0.25mg semaglutide weekly vs standard 0.25-2.4mg) to minimize gastrointestinal side effects while achieving mild appetite suppression

2025 Jan;182(1):52-68

Stangvaltaite-Mouhat L, Furberg AS, Drachev SN, Trovik TA

Future studies combining -cell states defined by scRNA-seq and snATAC-seq with quantitative measures of SCFA, indole derivatives, or endotoxemia have the potential to reveal whether specific -cell subpopulations preferentially associate with distinct microbiota-derived signatures or display differential transcriptional responses to incretin- and SCFA-dependent interventions, thereby advancing a systems-level understanding of microbiota-cell interactions
