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The amplified AMPK effect is a theoretical concern that has not been formally characterized in humans

N Engl J Med 383:721732 Steven S, Hollingsworth KG, Small P et al (2016) Weight loss decreases excess pancreatic triacylglycerol specifically in type 2 diabetes

By reducing appetite, GLP-1RAs may help facilitate the development of healthier eating habits, such as reduced portion sizes or improved nutritional quality, which may persist even after treatment is discontinued

Cut back on ultra-processed foods & added sugar Highly processed foods often contain hidden sugars, refined carbs, and artificial additives that increase cravings, encourage fat storage, and contribute to chronic inflammation [8]