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Food and Drug Administration (FDA) and do not undergo the same clinical studies as FDA-approved drugs to evaluate safety or efficacy." Compounded medications are prepared by licensed U.S

But within 12 months of stopping treatment, they regained two-thirds of the weight they had lost, along with a significant reversal of improvements in some cardiometabolic markers, such as those related to diabetes and heart disease

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Additionally, a multi-country study found substantial demand for GLP-1 medications among people without medical indications, highlighting the evolving landscape of body image and obesity treatment (Jensen et al., 2025)