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Dual-agonists such as GLP-1R/GIPR (e.g., Hengruis HRS9531) and triple-agonists such as GLP-1R/GIPR/GCGR (e.g., United Laboratories UBT251) represent the next technological wave, aiming for superior weight loss and broader metabolic benefits

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In clinical trials, GLP-1 RAs were shown to significantly lower blood pressure (BP) in addition to HbA1c and body weight (BW), indicating the possibility as anti-hypertensive medication of type 2 DM individuals