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Description
Common side effects (nausea, constipation, reduced appetite) typically diminish over weeks to months as your body adjusts

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Metformin: Co-administration of multiple twice-daily doses of sitagliptin with metformin, an OCT substrate, did not meaningfully alter the pharmacokinetics of metformin in patients with type 2 diabetes

S.et al (2014)
With semaglutide therapy, there is a titration period of approximately 8 weeks
