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If a dose is missed, FDA labeling recommends administering it as soon as possible within 4 days (96 hours) of the missed dose

Weight loss is off-label and rarely covered

The study included patients with HbA1c levels ranging from 7.0-10.0% (53-86 mmol/mol) who were being treated with diet and exercise with or without metformin

Co-administration of probenecid and 4-chlorokynurenineis is being evaluated in a phase 1 trial in healthy volunteers to determine if this boosting strategy can increase the CNS concentration of 7-chlorokynurenic acid (NCT05280054)

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