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However, gastrointestinal effects of these medicationsparticularly delayed gastric emptyingcould theoretically affect levothyroxine absorption if medications are taken simultaneously

Clinical trials do not consistently demonstrate significant tolerance development during the study periods

And that distinction matters more than people realize

doi: 10.1136/ard.2010.146399

All five medications share common allegations that their manufacturers knew or should have known about the risks of gastroparesis, intestinal obstruction, and other severe gastrointestinal injuries, yet failed to provide adequate warnings to patients and physicians