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GLP-1 RAs have been shown to induce phosphorylation and inactivation of NHE3 (Muskiet et al., 2017)

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In recent years, two classes of glucose-lowering medications,sodium-glucose cotransporter 2 inhibitors (SGLT2-I) and glucagon-like peptide-1 receptor agonists (GLP-1RA),have emerged as cornerstone therapies due to their robust cardiovascular and renal protective effects