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Description
Centrally, GLP-1 functions as a neuromodulator, with its receptor widely distributed in the brain, including the hypothalamus, NAc, ventral VTA, area postrema (AP), and potentially PFC [5,16] (refer to Table 1)
Rubino DM, Greenway FL, Khalid U, ONeil PM, Rosenstock J, Srrig R, et al
The study included the randomization of 247 adults with NASH without DM, who received pioglitazone (30 mg per day), Vitamin E (800 IU per day) or placebo for 96 weeks
Mol Neurobiol (2017) 54(10):807189
To rule out the possibility that lean mass loss following BW reduction could have affected creatinine-based eGFR measurement, the muscle mass-independent endogenous filtration marker cystatin C was used to confirm the renal favorable effects attributed to tirzepatide [52]
