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Additionally, the pharmacokinetic properties of -blockers can impact their potential for drug interactions and adverse effects, highlighting the importance of individualized treatment approaches ( 3 Pleiotropic properties of -blockers -blockers, traditionally known for their role in CVDs management, have been found to exhibit pleiotropic properties that extend beyond their primary pharmacological effects

In all in vitro and in vivo models used, tirzepatide was able to stimulate glucose-dependent insulin secretion via GIP and/or GLP-1 receptor activation

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Targeting GLP-1R expressed on microglia by NLY01 selectively inhibits microglial activation and induction of the reactive astrocyte inducers TNF-, C1q, and IL-1, thus protecting both mouse (5xFAD and 3xTg-AD mice) and human neurons in vitro (human embryonic stem cell (hESC)-derived human cortical neurons) [159]