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Summary GLP-1RA-mediated weight loss is achieved through multiple pathways including effects on the central nervous system such as reduced appetite, energy intake, and hunger, increased feelings of satiety, and altered food preferences

J Menopausal Med (2015) 21(2):93103.10.6118/jmm.2015.21.2.93 57 HeJWangCSunYLuBCuiJDongNet alExendin-4 protects bone marrow-derived mesenchymal stem cells against oxygen/glucose and serum deprivation-induced apoptosis through the activation of the cAMP/PKA signaling pathway and the attenuation of ER stress

This has been induced in persons who are overweight or obese with or without T2D [11,12]

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Their benefits now extend well beyond glycemic control and weight loss, with growing evidence supporting their use in the management of steatosis liver disease, obstructive sleep apnea, cardiovascular disease, and chronic kidney disease