glp-1 and dpp4 together degrade the GLP1 incretion, which leads to suppression of the Figure 1 from Emerging role
Description
And third, both studies were done specifically in people with prediabetes, who already have disrupted blood sugar regulation

Are GLP-1s to blame
This advantage continued over time, with engaged members seeing 29.1% greater average weight loss at 12 months
The cost to Medicare of covering obesity drugs under Part D has been estimated at between $25 billion and $35 billion over 10 years, which could have been a driving factor in the reluctance or unwillingness of major Part D plan sponsors to participate in the BALANCE model as it was originally designed

[3] American Diabetes Association (2022)