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It is driven primarily by glucagon receptor activation of the cAMP-PKA signaling pathway in cardiac tissue, which is a direct pharmacological effect rather than an indirect autonomic change

doi: 10.1210/jc.2009-0921

While weight loss has been linked to improving metabolic activity and heart pumping, as heart tissue and the walls of the blood vessels get thinner, and levels of cholesterol and triglyceride levels are known to become more stable, Novo Nordisk has claimed that Wegovys heart health benefits go beyond the effects of weight loss, at the American Heart Association (AHA) Scientific Sessions in the U.S., that took place in November