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The clinical challenge is therefore to manage treatment burden in a way that prevents early discontinuation, because only sustained, long-term therapy can optimise metabolic, cardiovascular, and weight related benefits
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Studies in non-fibromyalgia populations show average weight loss of 15-22% over 68 weeks on semaglutide, with sustained benefits when dosing is optimized
doi: 10.1124/pr.115.010629 86 CaoJBelousoffMJGerrardEDanevRFletcherMMDal MasoEet al
