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Large routines with too many products often become difficult to follow long-term, especially when appetite, hydration, and meal timing are already changing

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Ahrn B, Masmiquel L, Kumar H, et al

In a phase 2 clinical trial for obesity, 26 weeks of efinopegdutide (doses 5 to 10mg) resulted in up to 11.8% WL in people with obesity (without diabetes) compared to 7.5% WL with liraglutide 3 mg and 1.8% WL with placebo [77, 78]
Orforglipron also is more likely to increase heart rate (by about 4 beats per minute)
