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In this setting, daily administered GLP-1RAs added to basal insulin provides a less relevant improvement in glycemic control ( HbA 1c = -0.68%, 95% CI -0.92

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Diabetes, Metab Syndr Obes

But this experimental drug goes a step further by adding a third hormone, glucagon, earning it the nickname Triple G. In the Phase 3 Triumph-4 trial, Lilly tested two doses of retatrutide against a placebo in 445 people who were obese or overweight and also had knee osteoarthritis