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The primary end points were the percentage change in body weight and the change in the WOMAC pain score (on a scale of 0 to 100, with higher scores reflecting worse outcomes) from baseline to week 68

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The Collaborative Evidence Review for Obesity Management guidelines suggest sequential rather than parallel initiation when combining appetite suppressants

This very relationship runs like a thread through the whole body of data

Integrating a reduced-calorie diet, physical activity, and adequate protein intake ensures the medication's effectiveness in promoting muscle retention and significant weight reduction