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Description
Clinical Corner Benefits of using CGM with GLP-1 drugs for diabetes treatment Published: Jan
2024 Jun 18;15(1):5177
GLP-1 is able to stimulate cAMP formation in RIN 1046-38 cells, which in turn causes an increase in insulin mRNA levels and insulin release, and insulin accumulation in the culture fluid was observed by adding GLP-1 (7-37) to RIN 1046-38 cells for 1 h incubation (Drucker et al., 1987)
Mechanism of Action Semaglutide exerts its effects through selective agonism of the GLP-1 receptor (GLP-1R), a G-protein coupled receptor (GPCR) expressed in the pancreas, gastrointestinal tract, heart, vasculature, kidneys, and central nervous system
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