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Chronic cold stress in Glp1r-/-Gipr-/-, Glp1r-/-Glp2r-/-, and Glp2r-/- mice revealed distinct and overlapping roles for GLP-1R and GLP-2R in the expansion of the intestinal absorptive surface area expansion in response to chronic cold stress.

Altimmune just made a big move in the world of GLP-1 research, but this time, its not about obesity.The company announced yesterday that it has officially begun enrolling participants in a Phase 2 trial of pemvidutide, its GLP-1 and glucagon dual receptor agonist, to evaluate the drug in people with Alcohol Use Disorder, or AUD

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Based on a systematic synthesis of available findings, we conclude that there is considerable support for the neuromodulatory potential of gut-based circulating peptides on reward responses