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Poor sleep increases ghrelin (hunger hormone), decreases leptin (satiety hormone), and promotes insulin resistance
These appointments also provide an opportunity for you to discuss any concerns or side effects you may be experiencing

Additionally, they are all broken down similarly by dipeptidyl peptidase-4 (DPP-4) though GIP breakdown occurs at a slower rate than GLP-1 breakdown [16]

Traditional guidelines have emphasized metformin as initial treatment due to its proven safety, low cost, and cardiovascular benefits

this is probably a result of weight reduction rather than the medication's direct effects
