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Long term data out to 48 weeks did not demonstrate new or alarming risks

Musculoskeletal issues like leg pain were not prominently reported in these official studies, but real-world usage has shown that some individuals do experience discomfort that feels like it is centered in the muscles or joints of the lower body
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Citations Citations to this article as recorded by Limited Impact of Sodium-Glucose Cotransporter-2 Inhibitors on Appetite and Body Weight: Evidence From Clinical and Rodent Studies Joonyub Lee, Sohee Park, Evonne Kim, Ji-Yeon Park, Marie Rhee, Jing W

Several specific mechanisms are worth understanding: Berberine and AMPK activation
