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People with Certain Digestive Problems Some individuals with a history of severe gastrointestinal (GI) issues, like gastroparesis, a condition where the stomach takes too long to empty food, should avoid Semaglutide

This approach is only appropriate for individuals who have previously tolerated GLP-1 agonists

When Wegovy (Semaglutide) is taken with insulin and the insulin dose is reduced too quickly, it can lead to high blood sugar (hyperglycemia), which increases the risk of diabetic ketoacidosis

The most recently marketed Tirzepatide targets not only the GLP-1 receptors, but also the Glucose-dependent Insulinotropic Polypeptide (GIP) receptors, which have similar important functions in blood glucose regulation

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