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Description
Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )
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At the peripheral level, they support glycemic control and insulin sensitivity by promoting glucose-dependent insulin release from pancreatic -cells, inhibiting excess glucagon secretion, and slowing gastric emptying [20,21]
Liu C, Xu N, Zong Q, Yu J, Zhang P (2021) Hydrogel prepared by 3D printing technology and its applications in the medical field
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