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If severe nausea persists for more than 48 hours or you cannot keep any fluids down, contact your healthcare provider

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Tirzepatide and retatrutide have many similar potential side effects, including: nausea diarrhea constipation acid reflux decreased appetite Anyone on a weight loss med should be monitored by a clinician, who can keep an eye on your progress and help you navigate common side effects

The model accounted for extensive systemic metabolism through proteolytic cleavage via peptidases and renal elimination through kidney clearance, with the fraction of the drug eliminated in the urine fixed at 66%, as reported in the FDA Clinical Pharmacology Review (FDA, 2021)

The math works out cleanly, which is one reason pharmacies prefer this concentration