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Additional strategies under investigation aim to develop small-molecule GLP-1R modulators, sustained-release depot formulations, and combination regimens that pair GLP-1R agonists with complementary agents to maximise metabolic and organ-protective benefits

While both medications also help with weight loss, they are not FDA-approved for chronic weight management

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PlexusDx's Precision Peptide Genetic Test reveals predispositions in GLP-1 signaling pathways and may help provide context for treatment selection or prior response patterns

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