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Deficiency of ICC survival factors (insulin and IGF-1 promote the production of smooth muscle cell-produced stem cell factor, an important ICC survival factor) is detrimental to ICC [60]

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Further country-level analyses were conducted to evaluate the overall adoption of testing models in that region

A full evaluation will consider other factors, like waist circumference, energy levels, and how weight is impacting day-to-day life

GIPR agonists have not been utilised in the clinic, hence less is known about the potential effects of manipulating GIPR signalling in the context of cancer